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DATA SHEET
Tiaprem 50% Antibiotic Premix Kind Antibiotic Premix Formulation Antibiotic Premix Presentations 5 kg. Registry REG. SAGARPA Q - 2083 - 166
  • FORMULA
     INGREDIENTS: Guaranteed analysis Hydrogenated Tiamulin Fumarate 500 g excipient cbp 1 kg INERT INGREDIENTS: Inert ingredients up to 100%
  • DESCRIPTION
    Poultry: Prevention and treatment of chronic respiratory disease caused by Mycoplasmagallisepticum, infectious synovitis caused by Mycoplasma synoviae. Pigs: Treatment of enzootic pneumonia caused by Mycoplasma hyopneumoniae, swine dysentery, contagious pleuropneumonia, ileitis and leptospirosis. MECHANISM OF ACTION: Its mechanism of action is to inhibit protein synthesis, due to the 50S ribosomal level unit. It generates less resistance to tylosin, even in the case of mycoplasmas. Pharmacokinetics: Tiamulin is provided with food. After initial administration, reaches peak plasma levels in 2 to 4 hours and 85% is absorbed. It is excreted in a slower phase, mainly in the bile and renally. Given its slow excretion, drug antibacterial values are obtained for 24 hours. Serum have rapid increase phase (30 min), a short phase of platform (30 to 60 min) and a slow decline phase. It shows an enterohepatic circulation and is biotransformed in more than 20 metabolites, some of which have antibacterial activity. Elimination occurs in urine, bile and feces. Since it is a lipophilic basic drug with a pKa of 7.6, it reaches different tissues relatively easily and achieve significant concentrations in milk.
  • DOSE
    Oral mixed with food.
  • WARNINGS
    Not used for human consumption meat from treated animals up to 5 days after administration of the product. Store in a cool, dry place. Keep out of reach of children

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