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Flortec® Premix Premix Kind Premix Formulation Premix Presentations 20kg bag. Registry REG. SAGARPA Q - 2083 - 084
  • FORMULA
     INGREDIENTS: Guaranteed analysis florfenicol 20 kg excipient cbp 1 kg INERT INGREDIENTS Inert ingredients up to 100%
  • DESCRIPTION
    Chloramphenicol was the one of the first antibiotics obtained synthetically, was discovered in 1947 by Ehrlich at Yale University. It is obtained from a culture filtrate of Streptomyces Venezuela. It was characterized as an antibiotic of choice for a number of bacterial diseases by the following features: Broad spectrum, excellent intestinal absorption, plasma distribution, fast acting, plasma at 2 hours maximum concentrations, excellent distribution in tissues and body fluids, rapid removal (24 hours).A date has banned its use in many countries, including Mexico, because the waste it on products of animal origin for human consumption leads to accumulation of the drug in the body affecting the bone marrow (irreversible deletion) causing a state aNEM aplastic ia. Continuous use has led to the generation of bacterial resistance, which has decreased its preventive efficacy levels. Florfenicol is a broad spectrum antibiotic that was developed as an alternative as prohibition of animals for slaughter Chloramphenicol; has shown that a wider spectrum Chloramphenicol and even your other analog, thiamphenicol. Structural formula of FlorfenicolIt also has good activity against some bacteria are resistant to chloramphenicol, although some degree of cross resistance is conceived. Within its scope it highlights the effect of Actinobacillus pleuropneumoniae, Salmonella sp, Staphylococcus aureus, Staphylococcus epidermidis, rusiopathiae Erysipelothrix, Escherichia coli, Pasteurella multocida, Bordetella bronchiseptica, Acetinobacter, Shigella sp and Hemophilus sp.Since it is considered that the p-nitro group of chloramphenicol is causing aplastic anemia in humans, in the structure of Florfenicol some radicals are substituted, for example, the hydroxyl group of the third carbon has been replaced by a fluorine, maintaining Likewise in the space chloramphenicol and thiamphenicol as the p-nitro group by a sulfur radical it is replaced. Chloramphenicol and thiamphenicol can be inactivated by gender Enterobacteriae by acetylation of the hydroxyl at the carbon atoms 1 and 3, in the chain of propanediol, which does not occur in the Florfenicol because it has a fluorine bond, which apparently it results in having greater potency against pathogens as compared to its two analogues. Flortec PREMIX is effective: rapid control of clinical signs. Speedy recovery. Fewer relapses. Administration at any age. No toxicity problems. Pharmacokinetics The half - life of Florfenicol orally is 2.9 to 8.9 h after the first dose, and 13.4 3.1 h after the seventh dose. ACTION MECHANISM An antibiotic inhibits protein synthesis at the ribosomal level, ie, blocking the incorporation of amino acid and n the peptide chains of the proteins in transformation. Inhibits protein synthesis in bacteria and, to a lesser extent, in eukaryotic cells.Bacterins penetrates cells by facilitated diffusion. It acts primarily by binding reversibly to the 50S subunit ribosomal mode near the site of action of macrolides. It may also block mitochondrial protein synthesis in mammalian cells.
  • DOSE
    Administered from 1 to 2 kg per ton of feed (20 to 40 ppm) at the discretion of veterinarian for a period of 7 days. VIA AND ADMINISTRATION : Oral, mixed with food.
  • USE
    For the prevention and treatment of diseases of pigs caused by susceptible germs to Florfenicol and adjunct bacterial infections secondary to a viral disease.
  • WARNINGS
    WITHDRAWAL PERIOD should not be used for human consumption meat from treated animals until 24 hours after treatment. Store in a cool, dry place. Keep out of the reach of children.

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