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 DATA SHEET
Estrep-50 Streptomycin Sulfate Kind Antibiotic Formulation Injectable Presentations Flasks: 50g corresponding to reconstitute and diluent in sterile water to a final volume of 200 ml. Registry REG. SAGARPA Q -2083- 018
  • FORMULA
     INGREDIENTS: Guaranteed analysis Streptomycin base (as sulfate) 50 g INERT INGREDIENTS Inert ingredients up to 100%
  • DESCRIPTION
    DESCRIPTION After parenteral administration, the absorption of most of the streptomycin is complete and rapid. Streptomycin is poorly absorbed, reaching peak blood concentrations between 30 and 90 minutes, only about 10% of the two antibiotics bind to plasma proteins. Streptomycin is an extremely polar compound and therefore does not penetrate the cells and not easily reaches levels adequate eye and central nervous tissue, even with meningeal inflammation. The highest concentration in tissues is accomplished in the renal cortex are also obtained high levels in synovial fluid pleura, peritoneum and organs such as liver and lung. The serum half-life 2-3 hrs. Excretion is primarily by glomerular filtration, the 2 compounds excreted in active form. Pharmacokinetics Streptomycin formula is bactericidal for susceptible microorganisms under irreversible inhibition of protein synthesis, this happens as follows: 1. Insertion to bacteria by active transport and passive diffusion. 2. Inhibition of protein synthesis at the level of the 30S ribosomal subunit a) interfere with the initiation complex formation peptides. b) Inducing a misreading of the code template messenger RNA which causes the incorporation of incorrect amino acids in the peptide. c) Originate breaking polysomes nonfunctional monosomes. INDICATIONS In all species for infections produced by Gram negative, susceptible to the action of Streptomycin as E. coli, Salmonella, Leptospira, pneumonias Pasteurella sp, etc.
  • DOSE
    Cattle, horses, pigs, sheep and goats: 10 to 20 mg per kg body weight. Canines and birds: 25 to 50 mg per kg body weight. ADMINISTRATION: deep Intramuscular.
  • WARNINGS
    Do not use this product 30 days before slaughter of animals intended for human consumption. Not consume milk from cows treated 72 hours after the last treatment. No use in allergic any component of the formula animals. Keep out of the reach of children. Store in a fresh and dry place.

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